Schedule

The 2011 schedule is also available here in pdf format.

Thursday, November 17th, 2011

8:00-8:15

Introduction

Rod Bremner & Eldad Zacksenhaus

Session 1- Cell Cycle & Cell Survival Chairperson: Julien Sage

8:15-8:55	Gustavo Leone Keynote Speaker	Genetic Link between endocycle control and cancer: E2F8
8:55-9:20	David Cobrinik	Parsing the role of cell type specific circuitry in retinoblastoma genesis
9:20-9:45	Liang Zhu	Skp2 and E2F1 underpin cellular responses to Rb loss in tumorigenesis and homeostasis
9:45-9:55	Chiaki Takahashi	The RB-SREBP nexus where RB meets cell signaling and lipid metabolism

10:00 – 10:30 – Coffee Break

Session 2 - Chromosome Stability Chairperson: Eric Knudsen

10:30 -10:55	Nick Dyson	Suppressing CIN
10:55 -11:20	Fred Dick	Tumor suppression by the retinoblastoma gene in the absence of E2F transcriptional repression
11:20 -11:45	Hein te Riele	Functional profiling of the transcriptome of Rb/p107-deficient cells identifies the suppressors of anchorage independent growth
11:45 -11:55	Yan Chen	Targeting RANKL/RANK therapy inhibits Prkar1a-low subclass of osteosarcoma

12:00 – 1:30 – Lunch

Workshop – I: Genome-Wide Analysis of the Rb Pathway

12:15 - 12:20	Eldad Zacksenhaus	Overview - Klaus Fiebig – OGI Vision
12:20 - 12:35	David Macpherson	miRNA and retinoblastoma
12:35 - 12:50	David Goodrich	Tap-tag knockin mice for RB and E2f and Chip-seq
12:50 - 1:05	Jerome Korzelius	Studying the dynamics of Rbf/dE2F transcriptional regulation in the Drosophila midgut by tissue-specific ChIP-Seq
1:05 - 1:30	Open Discussion	Genome-wide analysis of Rb loss

1:30-3:30

Poster Session I

Odd Number Posters
*Leave posters up for both days

3:00 – 3:30 – Coffee Break

Session 3 - Cell Fate and Signaling Chairperson: Eldad Zacksenhaus

3:30-4:10	Jaqueline Lees Keynote Speaker	New Roles for Rb
4:10-4:35	Max Frolov	An embedded microRNA mir-11 limits the pro-apoptotic function of its host gene, dE2f1
4:35-5:00	Rod Bremner	How to block a tumor with Rb pathway defects
5:00-5:25	Julien Sage	The Rb family in cellular reprogramming

Dinner Reception to follow

Session 4 - Senescence, Transformation & Therapy Chairperson: Peter Sicinski

Chairperson: Peter Sicinski

8:15-8:55	Judith Campisi Keynote Speaker	Suppressing cancer from the outside: Control of the senescence-associated secretory phenotype by the p53 and pRB pathways
8:55-9:20	Eric Knudsen	Targeting the RB pathway therapeutically
9:20-9:45	Karl Munger	Oncogene-induced Senescence and the pRB signaling network
9:45-9:55	Alain de Bruin	Atypical E2Fs are novel regulators of angiogenesis through activating VEGFA transcription in cooperation with HIF

10:00 – 10:30 – Coffee Break

Session 5 - Phosphorylation

Chairperson: Rod Bremner

10:30 -10:55	Peter Sicinski	Cdk-independent functions of cyclins
10:55 -11:20	Eldad Zacksenhaus	What happens when pRb cannot be fully phosphorylated in vivo
11:20 -11:45	Steve Dowdy	Requisite Mono-Phosphorylation of RB During Early G1 Phase
11:45 -11:55	Lisa Julian	E2f3 isoforms control neurogenesis by regulating Sox2 expression

12:30 – 1:30 – Lunch

Workshop – II: Genome-Wide Analysis of the Rb Pathway Chairperson: Jacqueline Lees (TBC)

12:15 - 12:30	Larisa Litovchick DeCaprio Lab	The Dream Complex
12:30 - 12:45	Katrin Tschop	Identifying players in the functional network around pRB
12:45 - 1:00	Brenda Gallie	Not Knudson’s retinoblastoma: a new disease driven by the MYCN oncogene with normal RB1
1:00 - 1:30	Open Discussion	Genome-wide analysis of Rb loss

1:30-3:30

Poster Session II

Even Number Posters
*Leave posters up for both days

3:00 – 3:30 – Coffee Break

Session 6 - Post-Translational Modifications Chairperson: Fred Dick

3:30-4:10	Nick La Thangue Keynote Speaker	New Levels of Control in the Rb-E2F pathway
4:10-4:35	Seth Rubin	Structural mechanism of Rb inactivation
4:35-5:00	Luis Fajas	The Cdk 4-pRB-E2F1 pathway regulates whole body metabolism in health and disease
5:00-5:25	Phil Hinds	Reciprocal effects of Cdk 6 loss versus inactivation in murine bone development